Dana-Farberications at Harvard College – For Higher Science
When you ever puzzled why the progress in cancer research is so gradual regardless of billions being invested into fundamental analysis – Sholto David will present you why.
Overlook Asian papermills. Overlook Sicilian universities. They’re simply emulating what probably the most prestigious US analysis establishments educate. And you may’t get any extra prestigious than Harvard and its Dana Farber Most cancers Institute.
“Why do profitable and apparently clever surgeons really feel the necessity to play faux at biology analysis? Has Sam S. Yoon ever carried out an invasion or migration assay? […] if that is how he “supervises” his analysis does anybody belief his supervision of surgical procedure?” – Sholto David
Nicely, the extent of information forgery is pathetically amateurish and extreme. A lot that we might solely embody a fraction of it into this text, you’ll have to search Ken Anderson, Invoice Hahn and different protagonists on PubPeer to see how dangerous all of it actually is. In actual fact, it’s worse, as a result of we solely see the tiny tip of the fraud iceberg – picture information duplications, the final resort of a failed scientist after each different trick didn’t provdie the specified consequence. Billions of {dollars} had been burned for this cancerous trash science, but it surely made many educational careers, some acquired very wealthy, and full dynasties established themselves at Dana Farber.
None of Dana Farber researchers talked about on this article replied when requested to touch upon their PubPeer information.
By Sholto David
As the entire world furiously argues over whether or not the president of Harvard did or didn’t use some citation marks in the appropriate place, scientists on the affiliated Dana-Farber Most cancers Institute (DFCI) should breathe a sigh of aid, nobody has bothered to critically learn their analysis in years! Far worse skeletons than plagiarism lurk within the archives…
Laurie H. Glimcher
Beginning with Laurie H. Glimcher, who’s the President and CEO of the DFCI. Little doubt Laurie constructed her profession on papers like this one, in Nature Immunology (2003), which incorporates some spectacular contributions to artwork, however maybe to not science.
Neal N. Iwakoshi, Ann-Hwee Lee, Prasanth Vallabhajosyula, Kevin L. Otipoby, Klaus Rajewsky, Laurie H. Glimcher Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 Nature Immunology (2003) doi: 10.1038/ni907
Perhaps the coauthor Klaus Rajewsky might subject a correction blaming the up to date western blot {hardware} this time (versus “updated FlowJo software“).
Star scientists Michel and Andre Nussenzweig come from a well-known household of immunologists. Clare Francis checked out a few of their papers.
Laurie has a curious angle to correcting her work, though she has replied to 1 of my much less vital comments, she uncared for to answer the above subject (regardless of prompting); and for the next duplicated circulation cytometry plots, she offered this dismissive response:
“You need to attain out to Dr. Hidde Ploegh- the primary creator, Dr. Boaz Tirosh was in his laboratory.”
Nicely Laurie, it’s your paper, when you care about it being appropriate, you can very properly attain out your self!
Boaz Tirosh, Neal N. Iwakoshi, Laurie H. Glimcher, Hidde L. Ploegh XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells The Journal of Experimental Drugs (2005) doi: 10.1084/jem.20050575
Laurie co-authored a number of papers with Claudio Hetz. This “star neuroscientist” was investigated by his college, which launched a damning report, accusing Hetz of recklessness, negligence, and a problematic angle to analysis ethics. Hetz merely expressed remorse that he didn’t have entry to a greater model of Photoshop to extra convincingly manipulate his photos.
“…Dr. Hetz appears moderately to remorse that he didn’t have higher instruments for enhancing the figures, in order that the undeclared interventions would have gone unnoticed.” – College of Chile investigative report.
In February 2020 Laurie claimed on PubPeer that she had not been made conscious of what occurred with Hetz’s papers (maybe she ought to subscribe to For Higher Science e-mail alerts!). In any case this discovery didn’t immediate her into motion, by 2023, solely one of many 4 papers tagged on PubPeer along with her and Hetz as co-authors has acquired a reply from her, and none have been corrected or retracted. For instance, this undergraduate degree error of miscounted western blot lanes stays within the scientific report, with out remark or correction, within the prestigious journal Science, no much less:
Claudio Hetz, Paula Bernasconi, Jill Fisher, Ann-Hwee Lee, Michael C. Bassik , Bruno Antonsson, Gabriel S. Brandt, Neal N. Iwakoshi, Anna Schinzel, Laurie H. Glimcher, Stanley J. Korsmeyer Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha Science (2006) doi: 10.1126/science.1123480
The above paper has generated a prolonged PubPeer thread, discussing a number of splices within the supplementary figures.
William C. Hahn (Invoice)
The very subsequent entry on the DFCI leadership page is Laurie’s deputy, William C. Hahn who’s the Govt Vice President and Chief Working Officer, in addition to a member of the Broad Institute of MIT and Harvard. Whereas Laurie has just a few troubling papers and a lamentable angle to rectifying these errors, Invoice has a much more spectacular PubPeer record, together with 30 search outcomes, with eighteen pertaining to problematic photos. Invoice is the previous postdoc of Robert Weinberg, proprietor of a powerful PubPeer record too.
A breast most cancers basis celebrates its analysis heroes. Learn now right here about how nice US scientists from Harvard, MIT, Weill Cornell and MD Anderson remedy most cancers.
Invoice contributed this calamitous effort to the journal Most cancers Analysis in 2005.
Wen Chen, Jason D. Arroyo, Jamie C. Timmons, Richard Possemato, William C. Hahn Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity Most cancers Analysis (2005) doi: 10.1158/0008-5472.can-05-1103
I’d encourage anybody to look rigorously on the blots, the sides very clearly present that these are not merely bands with comparable shapes, however the identical bands copied and pasted.
“The Plaintiff is Professor Sabatini […] the self-described highly effective senior scientist, who had demanded intercourse of her when she was a graduate pupil ending her research and about to begin a fellowship on the Whitehead, in a program Sabatini would direct. […] And it’s the man who had made it clear – all through her…
The stench of the sacked MIT professor David M. Sabatini is rarely removed from these discussions. Invoice co-authored a 2006 paper in Cell with Sabatini, and in addition with MIT’s Eric Lander, who was beforehand Joe Biden’s high science adviser, however resigned following stories of bullying and misogyny.
Jason Moffat, Dorre A. Grueneberg, Xiaoping Yang, So Younger Kim, Angela M. Kloepfer, Gregory Hinkle, Bruno Piqani, Thomas M. Eisenhaure, Biao Luo, Jennifer Okay. Grenier, Anne E. Carpenter, Shi Yin Foo, Sheila A. Stewart, Brent R. Stockwell, Nir Hacohen, William C. Hahn, Eric S. Lander, David M. Sabatini, David E. Root A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen Cell (2006) doi: 10.1016/j.cell.2006.01.040
Invoice’s PhD pupil Richard Possemato, additionally an creator of the beforehand talked about paper, labored at MIT with Sabatini and is now professor at New York College. The bands in yellow containers are almost pixel-perfect similar on shut inspection.
We are able to shortly full the Cell, Nature, Science trifecta for this weblog put up with one other collaboration between Invoice and Sabatini printed in Nature which incorporates duplicated circulation cytometry histograms, sensibly tucked away within the supplementary information. James E. Bradner (previously govt committee member of Novartis, and simply final week introduced because the new chief scientific officer of Amgen) earns one other point out on For Higher Science.
Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner, Michael B. Yaffe The bromodomain protein Brd4 insulates chromatin from DNA damage signalling Nature (2013) doi: 10.1038/nature12147
This isn’t the one duplication of circulation cytometry histograms printed by Invoice; one other was beforehand recognized by Elisabeth Bik:
Sheila A Stewart, Derek M Dykxhoorn, Deborah Palliser, Hana Mizuno, Evan Y Yu, Dong Sung An, David M Sabatini, Irvin S Y Chen, William C Hahn, Phillip A Sharp, Robert A Weinberg, Carl D Novina Lentivirus-delivered stable gene silencing by RNAi in primary cells RNA (2003)
doi: 10.1261/rna.2192803
Invoice apparently collects collaborations with longevity weirdos, together with this paper with one other obnoxious David: the Harvard professor David A. Sinclair. One thing was clumsily hidden by cloning an oblong part from a close-by lane. What was hid? We are going to probably by no means know, however no less than one of many authors will need to have felt it was vital sufficient to cover.
Ron Firestein, Gil Blander, Shaday Michan, Philipp Oberdoerffer, Shuji Ogino, Jennifer Campbell, Anupama Bhimavarapu, Sandra Luikenhuis, Rafael De Cabo, Charles Fuchs, William C. Hahn, Leonard P. Guarente, David A. Sinclair The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth PLoS ONE (2008) doi: 10.1371/journal.pone.0002020
This discovering was beforehand talked about on For Higher Science when discussing the work of Leonard Guarente, Sinclair’s mentor:
“With out particular and credible allegations of analysis misconduct, MIT is unable to take any motion.”
In his quest to befriend anti-aging cheaters, Invoice has additionally travelled to Germany, the place he collaborated with the taking pictures star Karl Lenhard Rudolph (who later grew to become the nation’s most well-known zombie scientist).
Extra dangerous information for Karl Lenhard Rudolph: misconduct findings and a couple of 12 months funding ban from DFG. Excellent news: the worldwide scientific neighborhood stands to him in solidarity, no retractions, even some corrections gained’t be carried out.
The next paper stems from Rudolph’s time at Hannover Medical College, and it was due to this fact not a part of the 2016 misconduct investigation by the Leibniz Affiliation. The penultimate creator is Hannover Medical College’s present president, Michael P. Manns.
A Satyanarayana, R A Greenberg, S Schaetzlein, J Buer, Okay Masutomi, W C Hahn, S Zimmermann, U Martens, M P Manns, Okay L Rudolph Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling Molecular and Mobile Biology (2004) doi: 10.1128/mcb.24.12.5459-5474.2004
Invoice works with a number of prestigious collaborators, Massimo Loda is the present Editor-in-Chief of Molecular Most cancers Analysis, an AACR journal (a writer you will discover steadily on this weblog put up).
Meet Massimo Loda, the brand new EiC of Molecular Most cancers Analysis. Not regardless of, however due to his PubPeer report. Additionally meet his accomplice Michele Pagano!
Raanan Berger, Phillip G. Febbo, Pradip Okay. Majumder, Jean J. Zhao, Shayan Mukherjee, Sabina Signoretti, Okay. Thirza Campbell, William R. Sellers, Thomas M. Roberts, Massimo Loda, Todd R. Golub, William C. Hahn Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells Most cancers Analysis (2004) doi: 10.1158/0008-5472.can-04-2938
Price mentioning that Thomas M. Roberts is one other DFCI researcher and Harvard professor, and so is his former postdoc Jean Zhao; they’ve a PubPeer record of their very own, with and with out Invoice.
Right here is Invoice with one other DFCI colleague, James DeCaprio:
Anna A. Sablina, Wen Chen, Jason D. Arroyo, Laura Corral, Melissa Hector, Sara E. Bulmer, James A. DeCaprio, William C. Hahn The tumor suppressor PP2A Abeta regulates the RalA GTPase Cell (2007) doi: 10.1016/j.cell.2007.03.047
In 2020, DeCaprio corrected a Nature Cell Biology paper Park et al 2020 as a result of “the western blot picture for VINC in Fig. 3g was a replica of that for LSD1.” So duplicated blots ought to be corrected? Loads of work to be finished in that regard!
One other spectacular titan of trade, Invoice printed with present Head of International Product Growth and Chief Medical Officer of Roche, Levi Garraway in 2011.
Nikhil Wagle, Caroline Emery, Michael F. Berger, Matthew J. Davis, Allison Sawyer, Panisa Pochanard, Sarah M. Kehoe, Cory M. Johannessen, Laura E. MacConaill, William C. Hahn, Matthew Meyerson, Levi A. Garraway Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling Journal of Scientific Oncology (2011)
doi: 10.1200/jco.2010.33.2312
However don’t rush to alert Roche, their former International Head of Pharma Analysis and Early Growth was John C Reed, who was beforehand at Sanofi, and is now at Johnson & Johnson. Good to know that in Huge Pharma analysis is in such protected arms.
In 2018, the pharma large Sanofi appointed with John Reed a brand new R&D head. Apparently Sanofi doesn’t consider in PubPeer.
Extra troubling western blots in movement at DFCI, with Invoice because the penultimate creator.
Hailing Cheng, Pixu Liu, Zhigang C Wang, Lihua Zou, Stephanie Santiago, Victoria Garbitt, Ole V Gjoerup, J Dirk Iglehart, Alexander Miron, Andrea L Richardson, William C Hahn, Jean J Zhao SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis Science Signaling (2009)
doi: 10.1126/scisignal.2000369
And eventually for Invoice, one other paper in Nature, with Bob Weinberg, containing a number of splices, and a mirrored band (I additionally suppose the migration of the Giant-T bands appears uncommon). This paper has over 3000 citations… So most likely nothing pressing right here for Nature to deal with?
William C. Hahn, Christopher M. Counter, Ante S. Lundberg, Roderick L. Beijersbergen, Mary W. Brooks, Robert A. Weinberg Creation of human tumour cells with defined genetic elements Nature (1999) doi: 10.1038/22780
Irene M. Ghobrial
Transferring on to Irene M. Ghobrial, who’s the Senior Vice President for Experimental Drugs at DFCI. Irene works on a number of myeloma, steadily publishing along with her DFCI colleagues Kenneth C. Anderson, Nikhil C. Munshi, Teru Hideshima, Ruben Carrasco, and Yu-Tzu Tai.
What sort of analysis has elevated Irene to her present place?
In 2012 this epic fail was printed, Irene gained moral approval to aspirate bone marrow from most cancers sufferers and wholesome volunteers, however Determine 1 consists of three apparent duplications.
Feda Azab, Abdel Kareem Azab, Patricia Maiso, Teresa Calimeri, Ludmila Flores, Yang Liu, Phong Quang, Aldo M. Roccaro, Antonio Sacco, Hai T. Ngo, Yong Zhang, Brittany L. Morgan, Ruben D. Carrasco, Irene M. Ghobrial Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom’s macroglobulinemia Scientific Most cancers Analysis (2012)
doi: 10.1158/1078-0432.ccr-11-0111
Wouldn’t the volunteers be livid after present process such an invasive process? Can the info from a paper like this ever be rehabilitated?
Identical to hapless Chinese language papermills, Harvard scientists battle with photos of crystal violet stained cells. Maybe this technique is simply cursed?
Paola Neri, Li Ren, Abdel Kareem Azab, Matthew Brentnall, Kathy Gratton, Alexander C. Klimowicz, Charles Lin, Peter Duggan, Pierfrancesco Tassone, Adnan Mansoor, Douglas A. Stewart, Lawrence H. Boise, Irene M. Ghobrial, Nizar J. Bahlis Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion Blood (2011) doi: 10.1182/blood-2010-06-292243
One other blunder in troublesome migration and invasion experiments was printed with John Crown, an Irish politician and member of the twenty fourth Seanad on the time this paper was submitted.
Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown, Lorraine O’Driscoll miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer Molecular Most cancers (2014)
doi: 10.1186/1476-4598-13-71
Like her colleagues talked about above, Irene additionally has bother with counting, what number of Harvard researchers does it take to rely to seven I ponder?
Alissa Huston, Xavier Leleu, Xiaoying Jia, Anne-Sophie Moreau, Hai T. Ngo, Judith Runnels, Judy Anderson, Yazan Alsayed, Aldo Roccaro, Sonia Vallet, Evdoxia Hatjiharissi, Yu-Tsu Tai, Peter Sportelli, Nikhil Munshi, Paul Richardson, Teru Hideshima, David G. Roodman, Kenneth C. Anderson, Irene M. Ghobrial Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment Scientific Most cancers Analysis (2008) doi: 10.1158/1078-0432.ccr-07-1299
As with Invoice, there are many western blot duplications to take pleasure in, too.
Abdel Kareem Azab, Feda Azab, Simona Blotta, Costas M. Pitsillides, Brian Thompson, Judith M. Runnels, Aldo M. Roccaro, Hai T. Ngo, Molly R. Melhem, Antonio Sacco, Xiaoying Jia, Kenneth C. Anderson, Charles P. Lin, Barrett J. Rollins, Irene M. Ghobrial RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma Blood (2009) doi: 10.1182/blood-2009-01-199281
Ruben Carrasco is one other DFCI scientist and frequent collaborator of Irene’s. He’s listed as a former postdoc of Ronald DePinho (who brought on a monetary disaster as President of MD Anderson in Texas). Learn extra on Ron right here:
The MD Anderson Most cancers Heart, a part of the College of Texas and situated in Houston, is a huge hub of giant most cancers analysis cash, even for US requirements. Additionally they do a number of science there, which solely objective appears to be publishing in large journals so as to generate much more cash. If there…
Abdel Kareem Azab, Phong Quang, Feda Azab, Costas Pitsillides, Brian Thompson, Triona Chonghaile, John T Patton, Patricia Maiso, Val Monrose, Antonio Sacco, Hai T Ngo, Ludmila M Flores, Charles P Lin, John L Magnani, Andrew L Kung, Anthony Letai, Ruben Carrasco, Aldo M Roccaro, Irene M Ghobrial
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment
Blood (2012) doi: 10.1182/blood-2011-07-368050
Maybe one can solely be taught bad science from DePinho, who was the postdoctoral adviser for Ned Sharpless, topic of my final weblog put up.
“The President’s objective of ending most cancers as we all know it right now is grounded, partially, within the work of scientific discovery that Ned Sharpless has led at NCI”
Who could possibly be guilty for this supplemental silliness? The splice, which the authors didn’t attempt to disguise, is difficult to justify within the first place, by no means thoughts that loading controls had been merely borrowed from the above blot.
Michal Bar‐Natan, Dina Stroopinsky, Katarina Luptakova, Maxwell D. Coll, Arie Apel, Hasan Rajabi, Athalia R. Pyzer, Kristen Palmer, Michaela R. Reagan, Myrna R. Nahas, Rebecca Karp Leaf, Salvia Jain, Jon Arnason, Irene M. Ghobrial, Kenneth C. Anderson, Donald Kufe, Jacalyn Rosenblatt, David Avigan Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1 British Journal of Haematology (2017) doi: 10.1111/bjh.14493
Irene’s Italian mentee, Aldo Roccaro, beforehand labored on the DFCI and has subsequently returned to Italy, the place he now a scientific analysis director on the hospital in Brescia, and a member of the ethics commission.
Aldo M Roccaro, Antonio Sacco, Xiaojing Jia, Ranjit Banwait, Patricia Maiso, Feda Azab, Ludmila Flores, Salomon Manier, Abdel Kareem Azab, Irene M Ghobrial Mechanisms of activity of the TORC1 inhibitor everolimus in Waldenstrom macroglobulinemia Scientific Most cancers Analysis (2012) doi: 10.1158/1078-0432.ccr-12-1532
I’m additionally involved about photos of mice. Within the determine under, a bunch of mice has made a knight transfer throughout the web page, and transitioned between teams. Interested by what Irene’s workforce could have wished to show (lack of most cancers unfold of their favoured group) this seems to be a really handy error.
Yu Zhang, Michele Moschetta, Daisy Huynh, Yu-Tzu Tai, Yong Zhang, Wenjing Zhang, Yuji Mishima, Jennifer E. Ring, Winnie F. Tam, Qunli Xu, Patricia Maiso, Michaela Reagan, Ilyas Sahin, Antonio Sacco, Salomon Manier, Yosra Aljawai, Siobhan Glavey, Nikhil C. Munshi, Kenneth C. Anderson, Jonathan Pachter, Aldo M. Roccaro, Irene M. Ghobrial Pyk2 promotes tumor progression in multiple myeloma Blood (2014) doi: 10.1182/blood-2014-03-563981
One other problematic murine determine is proven under. This seems to be almost fully fabricated by taking repeated scans of some mice and labelling them as displaying a spread of various timepoints and therapy situations. Look rigorously on the positions of the tail, toes, fur, and components of noise across the mice.
Abdel Kareem Azab, Judith M. Runnels, Costas Pitsillides, Anne-Sophie Moreau, Feda Azab, Xavier Leleu, Xiaoying Jia, Renee Wright, Beatriz Ospina, Alicia L. Carlson, Clemens Alt, Nicholas Burwick, Aldo M. Roccaro, Hai T. Ngo, Mena Farag, Molly R. Melhem, Antonio Sacco, Nikhil C. Munshi, Teru Hideshima, Barrett J. Rollins, Kenneth C. Anderson, Andrew L. Kung, Charles P. Lin, Irene M. Ghobrial CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy Blood (2009) doi: 10.1182/blood-2008-10-186668
Kenneth C. Anderson (Ken)
As talked about beforehand, Irene steadily publishes with Kenneth C. Anderson (you could have observed above). Ken can also be a senior DFCI researcher. Maybe we are able to think about them as Ken and Barbie?
Fairly other than his collaborations with Irene, Ken has an intensive report of problematic papers with out Irene. These have been tagged on PubPeer over the past ten years. Maybe Ken has rotten luck in selecting his collaborators? Right here Ken teamed up with the beforehand talked about Ron DePinho and Ruben Carrasco for an inventive interpretation of western blotting his CEO Laurie is likely to be impressed by.
Daniel R. Carrasco, Kumar Sukhdeo, Marina Protopopova, Raktim Sinha, Miriam Enos, Daniel E. Carrasco, Mei Zheng, Mala Mani, Joel Henderson, Geraldine S. Pinkus, Nikhil Munshi, James Horner, Elena V. Ivanova, Alexei Protopopov, Kenneth C. Anderson, Giovanni Tonon, Ronald A. DePinho The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis Most cancers Cell (2007) doi: 10.1016/j.ccr.2007.02.015
How about this muddle in Nature Drugs, additionally with Ruben Carrasco:
Di Zhu, Zhongqiu Wang, Jian-Jun Zhao, Teresa Calimeri, Jiang Meng, Teru Hideshima, Mariateresa Fulciniti, Yue Kang, Scott B Ficarro, Yu-Tzu Tai, Zachary Hunter, Douglas McMilin, Haoxuan Tong, Constantine S Mitsiades, Catherine J Wu, Steven P Treon, David M Dorfman, Geraldine Pinkus, Nikhil C Munshi, Pierfrancesco Tassone, Jarrod A Marto, Kenneth C Anderson, Ruben D Carrasco The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells Nature Drugs (2015) doi: 10.1038/nm.3867
A remaining mix-up with Ruben Carrasco, who’s affiliate professor in Harvard together with his own lab at DFCI.
Masahisa Jinushi, Matthew Vanneman, Nikhil C. Munshi, Yu-Tzu Tai, Rao H. Prabhala, Jerome Ritz, Donna Neuberg, Kenneth C. Anderson, Daniel Ruben Carrasco, Glenn Dranoff MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma Proceedings of the Nationwide Academy of Sciences (2008) doi: 10.1073/pnas.0711293105
One other unfortunate selection in scientific collaborators? Ken teamed up with Harvard’s and For Higher Science superstar Carl Ronald Kahn.
Yu-Tzu Tai, Klaus Podar, Laurence Catley, Yu-Hua Tseng, Masaharu Akiyama, Reshma Shringarpure, Renate Burger, Teru Hideshima, Dharminder Chauhan, Nicholas Mitsiades, Paul Richardson, Nikhil C Munshi, C Ronald Kahn, Constantine Mitsiades, Kenneth C Anderson Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3′-kinase/AKT signaling Most cancers Analysis (2003) pubmed: 14522909
“not everybody within the analysis neighborhood accepts that the issue requires such consideration; some consider it’s overblown.” -Jeffrey Flier, emeritus dean of Harvard Medical College
James E. Bradner earns one other point out for his collaboration right here with Ken. Maybe it’s time for somebody to look rigorously at his work? He actually appears to be caught within the crossfire moderately rather a lot. Additionally put along with the assistance of DFCIs star oncologist Paul G. Richardson, described in 2022 as “a giant of cancer care in myeloma“.
Teru Hideshima, Jun Qi, Ronald M. Paranal, Weiping Tang, Edward Greenberg, Nathan West, Meaghan E. Colling, Guillermina Estiu, Ralph Mazitschek, Jennifer A. Perry, Hiroto Ohguchi, Francesca Cottini, Naoya Mimura, Güllü Görgün, Yu-Tzu Tai, Paul G. Richardson, Ruben D. Carrasco, Olaf Wiest, Stuart L. Schreiber, Kenneth C. Anderson, James E. Bradner Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma Proceedings of the Nationwide Academy of Sciences (2016)
doi: 10.1073/pnas.1608067113
Klaus Podar, previously of DFCI, and now a professor in Germany, contributed no less than two photoshopped efforts with Ken.
Marc S. Raab, Iris Breitkreutz, Giovanni Tonon, Jing Zhang, Patrick J. Hayden, Thu Nguyen, Johannes H. Fruehauf, Boris Okay. Lin, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson, Klaus Podar Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling Blood (2009) doi: 10.1182/blood-2008-05-157040
One other one by Podar and one other former postdoc of Ken’s, Yu-Tzu Tai (who continues to be at DFCI):
Yu-Tzu Tai, Gerrard Teoh , Boris Lin, Religion E. Davies, Dharminder Chauhan, Steven P. Treon, Noopur Raje, Teru Hideshima, Yoshihito Shima, Klaus Podar, Kenneth C. Anderson Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage The Journal of Immunology (2000) doi: 10.4049/jimmunol.165.11.6347
Steven P. Treon, director of DFCI’s Bing Heart for Waldenström’s Macroglobulinemia Analysis, is one other frequent co-author.
Guang Yang, Yangsheng Zhou, Xia Liu, Lian Xu, Yang Cao, Robert J. Manning, Christopher J. Patterson, Sara J. Buhrlage, Nathanael Grey, Yu-Tzu Tai, Kenneth C. Anderson, Zachary R. Hunter, Steven P. Treon A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia
Blood (2013) doi: 10.1182/blood-2012-12-475111
Nicholas Mitsiades and Constantine Mitsiades are apparently brothers, however not clones (as these blots are).
Dharminder Chauhan, Guilan Li, Daniel Auclair, Teru Hideshima, Paul Richardson, Klaus Podar, Nicholas Mitsiades, Constantine Mitsiades, Cheng Li, Ryung Suk Kim, Nikhil Munshi, Lan Bo Chen, Wing Wong, Kenneth C. Anderson Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays Blood (2003)
doi: 10.1182/blood-2002-10-3146
Constantine Mitsiades is now affiliate professor at DFCI, he and his brother have extra on PubPeer. Additionally they was once collaborators of Germany’s untouchable high ophtalmologist Antonia Joussen (see the fabrications in Poulaki et al 2002 and Poulaki et al 2004).
“The committee […] requests of you for future publications to evaluate properly forward and to query critically your duty for the contributions of the co-authors, additionally on your personal safety.”
The next research was probably performed in Japan, the place DFCI’s Teru Hideshima clearly has contacts, however one way or the other his postdoctoral advisor Ken has wrangled himself the senior authorship spot. What was his contribution right here I ponder?
Masaharu Akiyama, Osamu Yamada, Teru Hideshima, Takaaki Yanagisawa, Kentaro Yokoi, Kohji Fujisawa, Yoshikatsu Eto, Hisashi Yamada, Kenneth C Anderson TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes Biochemical and Biophysical Analysis Communications (2004) doi: 10.1016/j.bbrc.2004.02.080
A few of Ken’s associates appear curiously depending on him for their very own analysis profession; DFCI program director and Harvard professor Nikhil C. Munshi is an effective instance (there are others) who seems to have nearly no impartial exercise.
Noopur Raje, Shaji Kumar, Teru Hideshima, Aldo Roccaro, Kenji Ishitsuka, Hiroshi Yasui, Norihiko Shiraishi, Dharminder Chauhan, Nikhil C. Munshi, Simon R. Inexperienced, Kenneth C. Anderson Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma Blood (2005) doi: 10.1182/blood-2005-01-0320
Round 2010 Ken retracted three papers in fast succession (Okawa et al 2008, Tai et al 2009, Gatt et al 2010), apparently as a result of the cell strains had been blended up, and to be truthful, it does appear to be mixing issues up is moderately in Ken’s wheelhouse, but it surely does go away one questioning… Was an investigation into the affair ever held? Or had been the retractions prompted by secret investigation? How a lot analysis funding are you able to waste on these blunders at DFCI with none penalties or any public remark?
In conclusion: a swathe of analysis popping out of DFCI authored by probably the most senior researchers and managers seems to be hopelessly corrupt with errors which can be apparent from only a cursory studying the papers.
Think about what errors is likely to be discovered within the uncooked information if anybody was allowed to look!
Because it occurred to the Dean of Harvard Medical College, George Q Daley:
The 2015 Nature Cell Biology paper by the Spanish most cancers researcher Carlos Lopez-Otin and his US accomplice George Q Daley, stem cell titan and dean of Harvard Medical College, is being retracted. First creator and Lopez-Otin’s pupil Clara Soria-Valles brought on Daley much more bother: her subsequent groundbreaking paper was meant to be already printed, however…
As time marches on, strategies have turn into extra “genomical”, and in a number of methods, more durable to scrutinize. I had a go at replicating a number of the gene expression evaluation in Irene’s papers (for instance, see here), and it doesn’t look hopeful, but it surely isn’t value anybody’s time to jot down such feedback if apparent errors in photos are going to be left unmolested for years at a time.
In 2017, DFCI’s personal future Nobel Prize winner William G. Kaelin Jr wrote an opinion piece in Nature, lamenting the proliferation of papers specializing in “influence” moderately than robustness, burying weak information in dietary supplements, cherry selecting, and different poor practices, he didn’t point out fraud, though there are nonetheless some attention-grabbing quotes.
“The principle query when reviewing a paper ought to be whether or not its
conclusions are more likely to be appropriate, not whether or not it might be vital
if it had been true. Actual advances are constructed with bricks, not straw. “William G. Kaelin Jr Nature (2017)
What precisely is the constructing materials of selection at DFCI?
“Even after individuals have been telling you for, , 20 years or extra that it’s going to occur, nobody expects it.” -Gregg Semenza, Nobel Prize winner 2019
Credit score ought to go to the nameless and named commentors on PubPeer, Invoice and Ken’s papers have been annotated over the past ten years, I presume steadily by Clare Francis. Among the more moderen remark’s particularly on Irene’s papers had been left by me, typically with the assistance of ImageTwin.ai. Different identified contributors embody Cheshire, and Elisabeth Bik. Written with some assist from Leonid.
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